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Dr. Wang’s research focuses on developing innovative tools, technologies, and therapeutics that combine stem cell engineering and biomaterial engineering to promote tissue regeneration. The Wang Group engineers and develops stem cells, stem cell derivatives and biomaterial-based scaffolds for the treatment of surgical diseases. Our research interests include (1) engineering stem cells and stem cell-derived extracellular vesicles (EV) for tissue regeneration and targeted delivery, and developing instructive biomaterial scaffolds that mimic native extracellular matrices (ECM) for stem cell culture, expansion, delivery, and recruitment; (2) establishing and using experimental and naturally-occurring disease models to evaluate the function of novel regenerative therapeutics, such as cell, EV and ECM products; and (3) conducting investigational new drug (IND)-enabling studies, clinical trials in both companion animal and human patients, and academic entrepreneurship and commercialization.